Postdoctoral position in NMR Structural Biology - Paris Descartes University, Paris, France

Postdoctoral position in NMR Structural Biology - Paris Descartes University, Paris, Franceposted: November 29 200912 month post-doctoral position in Structural Biology NMR is open in Paris Descartes University.Funding for the position is provided by the French National Agency ofResearch (ANR) for 1 year.The postdoctoral position is available from April 1, 2010 in the ParisDescartes University to characterize the interaction of new HIV-1anti-integrase inhibitors with LEDGF-Integrase complex.The candidate will join the NMR & Molecular modeling team of thelaboratory of Chemical and Biochemical Pharmacology and Toxicology(UMR8601 CNRS), and be responsible for the development and structuralanalysis of HIV-1 integrase by high-resolution solution NMR andmolecular modeling. The main approach will be to characterize theinteraction by transfer-NMR experiments (STD, WaterLOGSY, ...) and toparticipate in the development of AuPosSOM software to classifymolecules according to their contact pattern with the target of interestand 2D/3D QSAR modeling. Candidate requirements Applicants should have a Ph.D. in Biochemistry, Chemistry or related fields.The candidate is expected to have a strong expertise in solution NMRwith in-depth training in NMR receptor-ligand interaction, proteinstructures and dynamics, and drug-protein interactions. Familiarity withbiochemistry, biophysics is desirable. Experience with molecularmodeling (docking, virtual screening, python language) would be a big plus. How to apply For any queries about the lab and research projects, please contactGildas Bertho by e-mail: gildas.bertho 'at" parisdescartes.frThis page was last modified 19:32, 3 February 2010.This page has been accessed 5,708 times. #J-18808-Ljbffr