Post-Doc position in Mechanical characterization of vascular ageing conditions - 24-month fixed[...]

Post-Doc position in Mechanical characterization of vascular ageing conditions - 24-month fixed-term contractThe CIS brings together 70 people, including 18 professors in engineering industrial/computing, biomechanics and healthcare engineering. Since its creation in 2004, the CIS has been representative of the ability of Mines Saint-Etienne to acquire leadership on innovative themes such as, for example, Soft tissue biomechanics. SAINBIOSE (INSERM UMR 1059) brings together researchers from the CIS (biomechanics, biomaterials and bioengineering), the faculty of Medicine from Jean Monnet University, Saint-Etienne University Hospital, Inserm and the French Blood Establishment. The global scientific objective of SAINBIOSE is a better understanding and of biostress in osteoarticular (LBTO team) and cardiovascular pathology (DVH team).Biomechanics, experimental and computational, is a major research topic of SAINBIOSE, which goes from modelling the mechanical behaviour of tissues to clinical and industrial applications, especially with the textile industry. In 2024, Prof Stéphane Avril was awarded an ERC Advanced grant from the European Research Council for the project JuvenTwin “Multiscale mechanobiological synergies in vascular homeostasis, ageing and rejuvenation”, which aims to establish multiscale digital twins of ageing effects on vascular mechanobiology and to simulate and screen effective rejuvenation treatments. This project will take place in a research group having 15 years experience in biomechanics and mechanobiology (https://emse.fr/~avril/). We open a non-permanent position of post-doctoral fellow to join the Avril’s team working on JuvenTwin’s project. The work will be carried out at Mines Saint-Etienne, within the SAINBIOSE research unit (Inserm U1059). It is based at the Centre Ingénierie et Santé (Hospital campus at the North of Saint-Etienne). The objective of the post-doctoral fellow will be to:Study the mechanics of cells embedded in hydrogels will confocal microscope to assess morphologies and measure traction forces using digital volume correlationTest excised aortas with custom computer-controlled extension-distension testing device combined with in situ multiphoton microscopy.Both techniques will be used to study the effects of vascular ageing on mechanobiology. A stay of 6 months at Yale University (Jay Humphrey’s lab) is planned.Tasks may change depending on the needs of the department and Mines Saint-Etienne.PROFIL SOUGHT:You are in one of the following situations:A doctoral degree no more than 3 years old, in which case you will be employed as a post-doctoral researcherIf your doctorate is more than 3 years old, you will be employed as a research and development engineerAnd ideally:Holder of PhD degree in biomechanicsYou have the following skills, knowledge and experience:Capacity to successfully integrate a team and a group within a R&D environmentGood knowledge of basic cell biologyFirst experience with testing vascular cells and/or blood vesselsExpertise in front-end and back-end developmentADDITIONAL INFORMATION:Fixed-term contract for a period of 24 monthsRemuneration will be set according to the candidate's profile, based on the rules defined by the Institut Mines Télécom's management frameworkFull timePosition based in Saint-ÉtienneFor internal use: Category II - Job P - Post doctorant according to the Management FrameworkThe position is open to all, with accommodation available on request for candidates with disabilities. The job is open to civil servants and/or the general public. All applications may be subject to an administrative enquiry.How to apply:Applications (CV, covering letter, letter of recommendation if applicable) must be submitted on the RECRUITEE platform no later than 23/08/2024:Candidates selected for an interview will be informed rapidly. Part of the interview will be held in English.As part of its Equality, Diversity and Inclusion policy, École des Mines de Saint Etienne is an employer that is committed to fair treatment of all applicants.For more information:For further information about the position, please contact:For all administrative information, please contact: #J-18808-Ljbffr