POST-DOCTORAL IMMUNOLOGY (M/F)

LaboratoryThe project will be developed within the Cancer Immunotherapy Center at the Immunology Department (INSERM Unit U932, https://curie.fr/unite/u932), headed by Ana-Maria Lennon. Unit U932 comprises 10 independent research teams in fundamental and applied immunology, working in a highly collaborative and international environment.The candidate will work under the supervision of Dr. Claire Hivroz, who heads the “Integrative Analysis of T Cell Activation” team https://institut-curie.org/team/hivroz within U932. The team studies how intracellular signaling mechanisms regulate the immune T cell responses. Their approaches are multidisciplinary, combining high-resolution fluorescence microscopy, biochemistry, cell biology, and mouse models. The team has extensive expertise in the analysis of signaling pathways induced by the TCR and its co-activators or co-inhibitors, and in characterizing the immune synapse. The team's aim is to build on this expertise to identify new molecular players and test their potential as immunotherapy targets.MissionsIn this context, the team is studying how CAR signaling differs from TCR signaling.The candidate's project will be in line with this study and will aim to:Characterizing intracellular CAR signaling in T lymphocytes.Testing new targets to enhance the efficacy of CAR-Ts in tumor models.The candidate will also interact with the Myeloid Cells and Immunity team https://curie.fr/equipe/benaroch. #J-18808-Ljbffr