Postdoc in Spatiotemporal organization of mRNA nuclear biogenesis, from chromatin to the nuclea[...]

Postdoc in Spatiotemporal Organization of mRNA Nuclear Biogenesis, from Chromatin to the Nuclear Pore ComplexAvailable from: January 1, 2016 to December 6, 2018While most of the molecular actors involved in the biogenesis and export of messenger ribonucleoparticles (mRNPs) have been characterized, their molecular interplay, the spatiotemporal organization of these processes, as well as their intricate relation with chromatin dynamics remains elusive. We recently reported that histone marks and chromatin remodelers could impact mRNP biogenesis independently of the transcription process. We aim to deepen our understanding of these fundamental questions using the model organism S. cerevisiae. This will be addressed through a combination of approaches including genetics, molecular biology (ChIP, RNA-IP, CRAC, RNAseq), and microscopy (live-cell imaging). #J-18808-Ljbffr